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GAK (protein)
Cyclin G-associated kinase (GAK) is a serine/threonine kinase that in humans is encoded by the ''GAK'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2580 )〕
==Function==
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5.〔
Cyclin G-associated kinase received its name because it immunoprecipitated with cyclin G though it now appears to not be associated with it. Cyclin G-associated kinase is homologous in function to the protein auxilin which when in association with Hsc70 uncoats clathrin in neuronal cells. However, the location of Cyclin G-associated kinase is not in the brain but near the trans-Golgi network of non-neuronal cells such as those found in the liver and testes. GAK is also known to be associated with focal adhesions though the exact relationship between the two is unknown.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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